One-third of US reproductive-aged women have a chronic medical condition. People with chronic conditions often consider their health status in reproductive decision-making, including potential disease-specific risks of both pregnancy and contraception. People with chronic conditions may face societal pressures related to stigmatization of pregnancy and parenthood for people with their condition. For some individuals with chronic conditions, long-acting reversible contraception (LARC) may be a safe and highly effective method of pregnancy prevention when desired. However, excessive promotion of LARC by clinicians for people with chronic conditions may become coercive, echoing the forced sterilization of people with certain disabilities in the recent past. Within this complex history, little is known about patterns of LARC use, especially duration of use, among people with chronic conditions, particularly in the context of their preferences, values, reproductive goals, illness perceptions, and experiences of societal influences. In this mixed methods study, we will pair 1) quantitative analysis of initiation and duration of LARC use in national Medicaid claims data from 2016-2021 for people with selected chronic diseases compared to controls and 2) qualitative interviews with 90 females ages 18-35 years old with selected chronic conditions who have ever used LARC to explore their narratives of LARC use and preferences for care. We will focus on epilepsy, cystic fibrosis, and diabetes because of the established reproductive implications of these conditions, evidence that people with these conditions make reproductive decisions while considering their health status, and potential variability in LARC use between and among people with these conditions.