The effect of feticidal injection on uterine artery blood flow in second trimester abortion
Abortion
Awarded 2026
Uta Landy Complex Family Planning Scholars
Maria Isabel Gonzaga, MD
University of Southern California
$7,500

Rationale: The clinical utility of induced demise prior to second-trimester abortion is debated. A proposed benefit of induced feticide is decreased blood flow to the uterus, thereby decreasing risk for blood loss during the procedure, however studies to further examine this change in physiology are needed. Objectives: (1) Analyze the change in uterine artery doppler pulsatility index (UAD PI) before and after feticidal injection. (2) Explore the association between blood loss at the time of dilation and evacuation and change in UAD PI related to feticidal injection. Study population: Patients with a singleton, non-anomalous intrauterine pregnancy requesting termination between 20-23 6/7 weeks gestation. Patients ineligible for feticidal injection with lidocaine (or cervical preparation with mifepristone) will be excluded. Methodology: This observational case series will recruit via convenience sampling. In alignment with routine and standard practice, all patients at LAGMC requesting termination of pregnancy are offered feticidal injection. UAD PI will be collected prior to feticidal injection, after confirmation of asystole, and immediately prior to dilation and evacuation or termination induction. Quantitative blood loss and management of excess bleeding will be assessed. Additional information will be collected on patients declining feticidal injection for baseline comparison. Analysis plan: Descriptive statistics will be reported. A paired t-test will be used to analyze change in UAD PI pre- and post- feticidal injection within patients.